2-FDCK

2-Fl-2′-Oxo-PCM (other names: 2-Fluorodeschloroketamine, 2-FDCK, 2-FK, 2-Fluroketamine, Fluoroketamine) is a dissociative agent of the arylcycloheximine class, analogous to deschloroketamine (DCK) and ketamine with a similar structure.

History
2-FDCK was developed as a designer substance, a replacement for deschloroketamine( DCK) in 2017.

Chemistry
2-FDCK contains a substitution of fluorine in its phenyl ring. This substance includes a cyclohexane ring connected to an aromatic ring with an amino group and contains a phenyl ring connected to a cyclohexane ring substituted with a ketone group, the aminomethyl chain is connected to the adjacent alpha-carbon (R2) of the cyclohexanone ring, the phenyl ring is replaced in R2 with a fluorogroup.

Pharmacology
This substance is relatively new and little data is available on its pharmacological and toxicological properties, all information is based on studies in rats.
2-Fluorodeschloroketamine is an NMDA receptor antagonist.
Its effects are highly dose-dependent, it can cause stimulation, sedation, anaseia, euphoria, dissociative effects, hallucinations.
Side effects include nausea, dizziness, loss of balance, double vision…
Tolerance develops with prolonged and repeated use; it takes 1-2 weeks to return to baseline levels after using the drug.

Legal status
Germany: NpSG, Industrial and scientific use only
UK: Class B controlled substance
Canada: Schedule I
Austria: prohibited substance production and sale
Italy: controlled substance
Latvia : controlled substance
Sweden: controlled substance
Switzerland: controlled substance
Turkey: controlled substance
Japan: controlled substance
Singapore: controlled substance
Technical Information:

Product Name: 2-FDCK
Other Name(s):  2-Fl-2′-Oxo-PCM, 2-Fluorodeschloroketamine, 2-FK, 2-Fluroketamine, Fluoroketamine
IUPAC Name: 2-(2-fluorophenyl)-2-(methylamino)cyclohexan-1-one
CAS: 111982-50-4
Molar Mass: 221.27 g/mol
Molecular Formula: C13H16FNO
InChi Code: InChI=1S/C13H16FNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3
InChIKey: PHFAGYYTDLITTB-UHFFFAOYSA-N
Canonical SMILES: CNC1(CCCCC1=O)C2=CC=CC=C2F
Formulation: A crystalline solid
NMR 2-FDCK