HDMP-28

Methylnaphthidate (other names: HDMP-28, DL-Threo-methylnaphthidate) is a stimulant of the group of substituted phenidate, a homologue of methylphenidate, which has similar effects.

Chemistry
The difference between methylnaphthidate and methylphenidate is the replacement of the main phenyl ring with a naphthalene group.

Pharmacology
HDMP-28 is a relatively new drug and there is little data on its toxicological and pharmacological properties, all the information provided is based on studies in mice.
Methylnaphthidate acts as a monoamine reuptake inhibitor with a difference from the standard dopaminergic stimulants and is a serotonin reuptake inhibitor.
This substance causes effects such as stimulation, quickened thinking, increased concentration, increased blood pressure, teeth grinding, increased action and euphoria.

Dosage
Threshold 4 mg
Light 10 – 15 mg
Common 15 – 30 mg
Strong 30 – 50 mg
Heavy 50 mg +
Duration
Total 2 – 5 hours
Onset 1 – 10 minutes
Peak 1.5 – 2 hours
Offset 1.5 – 2 hours
After effects 1 – 8 hours
Legal status
Germany: NpSG (Industrial and scientific use only)
Switzerland: Controlled substance by law
UK: Class B
Canada: Schedule III
Technical Information:

Product Name: HDMP-28
Other Name(s): Methylnaphthidate, DL-Threo-methylnaphthidate
IUPAC Name: methyl (2R)-2-naphthalen-2-yl-2-[(2R)-piperidin-2-yl]acetate
CAS: 231299-82-4
Molar Mass: 283.4 g/mol
Molecular Formula: C18H21NO2
InChi Code: InChI=1S/C18H21NO2/c1-21-18(20)17(16-8-4-5-11-19-16)15-10-9-13-6-2-3-7-14(13)12-15/h2-3,6-7,9-10,12,16-17,19H,4-5,8,11H2,1H3/t16-,17-/m1/s1
InChIKey: DNRNSIJBSCBESJ-IAGOWNOFSA-N
Canonical SMILES: COC(=O)C(C1CCCCN1)C2=CC3=CC=CC=C3C=C2
Formulation: A crystalline solid
NMR HDMP-28